SAMEER was set up as an autonomous R & D laboratory at Mumbai under the then Department of Electronics, Government of India with a broad mandate to undertake R & D work in the areas of Microwave Engineering and Electromagnetic Engineering Technology. It is an offshoot of the special microwave products unit (SMPU) set up in 1977 at the TATA INSTITUTE OF FUNDAMENTAL RESEARCH (TIFR), Mumbai. SAMEER, Mumbai was setup in 1984.

Centre for Electromagnetic Environmental Effects (E3) of SAMEER, located in Visakhapatnam, was established in June, 2014. SAMEER-E3 Centre has been pursuing its objective of doing Electromagnetic Environmental Effects (E3) Research, Development, Test, and Evaluation with specialized E3 test facilities as per MIL STD 461E/F,464 and MIL STD 188-125-1&2. The E3 test facility specializes in a variety of capabilities, ranging from box level to complete system level testing.